Amantadine to Speed Awakening After Cardiac Arrest

• Status: Completed
• Trial end date: 2018-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation. Half of the participants will receive amantadine and the other will receive placebo.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jon Rittenberger, MD; University of Pittsburgh
• Collaborator: American Heart Association
• Treatments: Amantadine

Criteria

Inclusion Criteria:

• Non traumatic cardiac arrest

• Age 18 and older

• Defibrillation and/or chest compressions by healthcare providers

• Return of spontaneous circulation

Exclusion Criteria:

• Written do not attempt resuscitation (DNAR) reported to providers before randomization

• Known prisoner or pregnancy

• Lack of motor response to pain and absent N20 response on somatosensory evoked potentials prior to randomization

• Initial CT demonstrating brain edema (defined as grey white ratio <1.2)

• Presence of malignant pattern on EEG at time of randomization

• Next of kin unwilling to provide supportive care for at least one week after enrollment

• Presently using other dopaminergic agent