Amelioration of Polycystic Ovary Syndrome Related Disorders by Supplementation of Thymoquinone and Metformin
Status:
Completed
Trial end date:
2020-08-31
Target enrollment:
Participant gender:
Summary
Objective: To investigate the potential benefit of adding Thymoquinone to Metformin in
alleviating symptoms of polycystic ovarian syndrome.
Methods: 207 overweight and obese PCOS Patients were divided into two groups. Patients in
Group A, received Metformin 500 mg three times daily for 6 months. Patients in Group B,
received a combination of Metformin 500 mg and Thymoquinone in the form of Black Cumin oil
500 mg capsules three times daily for 6 months. Follow up was done after 3 and 6 months from
the beginning of the study for evaluation of menstrual cycle pattern, body mass index, Waist
circumference, Hip circumference, and Waist / Hip ratio, Oral glucose tolerance test,
Glycosylated Hemoglobin A1C, Superoxide dismutase activity and Malondialdehyde concentration.