American Ginseng Treatment for Multiple Sclerosis Related Fatigue

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This research project will determine the safety and tolerability of ginseng in subjects with MS and will gather preliminary data on the efficacy of ginseng vs placebo for the treatment of MS fatigue.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oregon Health and Science University
• Collaborator: National Multiple Sclerosis Society

Criteria

Inclusion Criteria:

• MS as diagnosed by the McDonald criteria

• Complaint of fatigue that has been persistent for at least 2 months

• FSS score of 4 or greater;

• Age 18-70.

Exclusion Criteria:

• Use of ginseng or stimulants in the prior 6 weeks

• Acute treatment with glucocorticoids in the prior 6 weeks

• BDI >31

• Significant MS exacerbation in prior 30 days

• Diabetes

• Uncontrolled hypertension

• Other serious medical disease, pregnancy or breastfeeding

• Breast disease

• Abnormal bleeding or clotting disorder

• Current use of warfarin, albendazole, nifedipine, digoxin, bumetadine, selegiline, isocarboxazid, or phenelzine

• Current use of lasix for poorly controlled hypertension or congestive heart failure

• Current drug or alcohol abuse; inability to complete the self report forms