Optic neuritis (ON) is a common event in Multiple Sclerosis (MS), and causes significant loss
of nerve cells in the eye, resulting in poor vision. Optic neuritis also provides a sensitive
way of testing the effectiveness of drugs that may help protect from loss of nerve cells in
ON and therefore in MS.
The investigators have identified through laboratory and early clinical research in humans
that amiloride (a water tablet already in use) may be a drug that can be of benefit in optic
neuritis by protecting from loss of nerves cells, ie a neuroprotective drug.
The purpose of this study is to assess the efficacy of amiloride as a neuroprotective drug in
optic neuritis
Phase:
Phase 2
Details
Lead Sponsor:
University of Oxford
Collaborator:
Multiple Sclerosis Society of Great Britain and Northern Ireland