Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This was a prospective, randomized, double blinded study in which patients undergoing a cardiopulmonary bypass (CPB) with aortic cross clamping were randomly assigned to receive amiodarone, lidocaine, or saline placebo prior to removal of the aortic cross clamp. (CPB is a technique that temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the body.) Specifically, we will test the hypothesis that amiodarone is superior to both lidocaine and placebo in the prevention of a severely abnormal heart rhythm when the blood flow is restored to the heart after the aortic cross clamp is removed.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Amiodarone; Anti-Arrhythmia Agents; Lidocaine

Criteria

Inclusion Criteria:

• Patients undergoing cardiac surgery that was expected to include cross-clamping of the aorta

Exclusion Criteria:

• Women wishing to become pregnant within 6 months of surgery

• Allergy to amiodarone

• History of organ dysfunction due to previous amiodarone use

• Patients who require more than mild systemic hypothermia (<32 degrees C) during cardiopulmonary bypass

• Patients who require more than one bypass run or more than one period of aortic cross-clamping