Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
The adhesive capsulitis is a disease of the shoulder characterized by pain and limitation of
movement amplitude. It is defined as for etiology, having discordant theories that related it
to an inflammatory condition or to an algoneurodystrophy process. There is not yet a
consensus about the best option of treatment. The non-steroidal anti-inflammatories have
analgesic and anti-inflammatory activity, where the mechanism of action is the inhibition of
prostaglandin synthesis. The antidepressants have been increasingly used in the control of
chronic pain and the major action mechanism to have the analgesic effect seems to be based on
inhibition of neurotransmitters reuptake noradrenaline and/or serotonin) in nerve cell
endings. Literature studies associate the practice of the nerve suprascapular blockade with
anaesthetics to good results of clinical improvement of the pain, however, so far, no
clinical studies comparing the efficacy of the non-steroidal antiinflammatories or tricyclic
antidepressants to nervous blockage were registered in the acute treatment of adhesive
capsulitis.
Phase:
Phase 2
Details
Lead Sponsor:
Universidade do Sul de Santa Catarina
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination Nimesulide