Amoxicillin Susceptibility of Oral Streptococci After a 3-Day or a 7-Day Amoxicillin Therapy

• Status: Terminated
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Antibiotic resistance is a worldwide problem closely linked to antibiotic consumption. To limit the risk to select resistant bacteria, the rules of prescription are to use high doses and short durations of treatment. The purpose of this study was to evaluate the interest to reduce amoxicillin treatment from 7 days to 3 days, in cases of odontogenic infection requiring the extraction of the tooth associated with amoxicillin monotherapy. The 3-day treatment will be compared to the classical 7-day treatment for clinical efficacy (pain, wound healing) and impact on the susceptibility of oral streptococci to amoxicillin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Amoxicillin

Criteria

Inclusion Criteria:

• odontogenic infection requiring tooth extraction asociated with amoxicillin monotherapy

• good condition

• 18-60 years old

• written informed consent provided

Exclusion Criteria:

• antibiotic prophylactic treatment

• special infectious risk (immunodeficiency, diabetes..)

• pregnant or breastfeeding women

• amoxicillin contraindication

• antibiotic treatment during the lasts 45 days