Amoxicillin and Metronidazole During or After the Periodontal Treatment

• Status: Active, not recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This randomized clinical trial aimed to compare the clinical and microbiological effects of different times of administration of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of periodontitis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Belén Retamal-Valdes
• Treatments: Amoxicillin; Metronidazole

Criteria

Inclusion Criteria:

• 18 years of age;

• at least 15 teeth (excluding third molars and teeth with advanced decay indicated for extraction);

• a minimum of 6 teeth with at least one site each with probing depth (PD) and clinical attachment level (CAL) ≥5 mm;

• at least 30% of the sites with PD and CAL ≥4 mm and bleeding on probing (BOP).

Exclusion Criteria:

• pregnancy;

• breastfeeding;

• current smoking and former smoking within the past 5 years;

• systemic diseases that could affect the progression of periodontitis (e.g. diabetes, immunological disorders, osteoporosis);

• scaling and root planing in the previous 6 months;

• antibiotic therapy in the previous 6 months;

• long-term intake of anti-inflammatory medications;

• need for antibiotic pre-medication for routine dental therapy;

• use of orthodontic appliances;

• extensive dental prosthetic rehabilitation;

• allergy to metronidazole and/or amoxicillin.