Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic debridement (FMUD) with AM (Amoxicillin + Metronidazole) for the treatment of Generalized Aggressive Periodontitis (GAgP).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Campinas, Brazil
• Treatments: Amoxicillin; Metronidazole

Criteria

Inclusion Criteria:

• diagnosis of GAgP;

• presence of 20 teeth;

• presence of teeth presenting PD>5 mm with bleeding on probing (BOP) and 2 teeth with PD>7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them);

• good general health;

• <35 years of age.

Exclusion Criteria:

• were pregnant or lactating;

• were suffering from any other systemic diseases (e.g., cardiovascular, diabetes);

• received antimicrobials in the previous 3 months;

• were taking long-term anti-inflammatory drugs;

• received a course of periodontal treatment within the last 6 months;

• smoked