Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis
Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
This study will examine the effectiveness and safety of a combination treatment for
cryptococcal meningitis, a fungal infection common in persons with acquired immune deficiency
syndrome (AIDS) in the developing world. The standard initial treatment includes two
medications: amphotericin B for 2 weeks followed by 8 weeks of fluconazole. This study will
look at whether study participants recover more quickly and have fewer side effects if they
are given both drugs at the same time for 2 weeks followed by 8 weeks of fluconazole as
compared to the standard treatment. Participants will be followed for approximately 6 months
from the time they are enrolled into the study.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Amphotericin B Fluconazole Liposomal amphotericin B