Ampicillin/Sulbactam Versus Cefuroxime as Antimicrobial Prophylaxis for Cesarean Section

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of cefuroxime at cord clamp for prevention of postcesarean infectious morbidity has not been assessed.

Women scheduled for cesarean delivery were randomized to receive a single dose of either 3g of ampicillin-sulbactam or 1.5g of cefuroxime intravenously, after umbilical cord clamping. An evaluation for development of postoperative infections and risk factor analysis was performed.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Attikon Hospital
• Treatments: Ampicillin; Anti-Infective Agents; Cefuroxime; Cefuroxime axetil; Sulbactam; Sultamicillin

Criteria

Inclusion Criteria:

• All patients undergoing a cesarean delivery were eligible.

Exclusion Criteria:

• Patients with known hypersensitivity to penicillin or cephalosporins.

• Patients who required concomitant antibiotic therapy during surgery.

• Patients who have received antibiotics during the 72 hours immediately preceding their enrollment.

• Patients whose postpartum fever was clearly associated with other known causes.