Overview

An Add-On Trial of Quetiapine in Patients With Bipolar Disorder and Cocaine Dependence

Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine if quetiapine add-on therapy is associated with a decrease in cocaine use and craving and a greater improvement in mood.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Texas Southwestern Medical Center
Treatments:
Cocaine
Quetiapine Fumarate
Criteria
Inclusion Criteria:

- Bipolar Disorder, type I; Cocaine Dependence with use in the past 7 days; Currently
taking a mood stabilizer; Meets criteria for a hypomanic or manic episode

Exclusion Criteria:

- Bipolar Disorder, type II, NOS; Cyclothymia; Other substance dependence; Diabetes;
Initiated therapy in the past 2 weeks; History of cataracts or likely cataracts;
Current active suicidal or homicidal ideation; Life threatening medical condition;
Mental retardation, dementia or severe cognitive impairment; Pregnant or nursing
womenon; antipsychotic within 7 days of beginning Quetiapine therapy or have initiated
antidepressants or mood stabilizers or psychotherapy within the past two weeks.