Fasting is a known trigger for headache. People who fast to comply with religious edict have
been shown to be prone to headache which becomes more likely to occur with increasing length
of fasting, and in people prone to headache. This has been documented as 'Yom Kippur
Headache' and 'First of Ramadan Headache.' We performed a study to test the hypothesis that
Rofecoxib, a pain medicine and anti-inflammatory, with a prolonged duration of action would
prevent or attenuate headache when taken just prior to the complete (no food or drink) 25
hour fast of Yom Kippur.