An Exploratory Haemodynamic Study in Patients With Compensated Cirrhosis and Portal Hypertension
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The main purpose of this exploratory study was to investigate the effect of serelaxin
(RLX030) infusion on the hepatic and renal circulation in patients with compensated cirrhosis
and portal hypertension. Measurements were acquired non-invasively using magnetic resonance
angiography (MRA) (study part A) and more directly via cannulation of the hepatic portal vein
during a routine transjugular intrahepatic portosystemic shunt (TIPSS) check procedure (study
part B), to determine the acute haemodynamic response to serelaxin (RLX030).