An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
Patients with abnormal kidney function are at increased risk for complications following
heart surgery, including worsening kidney function possibly requiring dialysis, a prolonged
stay in the critical care unit and hospital, and the increased risk of death. Prior attempts
at kidney protection for heart surgery patients have had mixed results. Two medicines,
fenoldopam and N-acetylcysteine, have been shown to protect kidney function in other
circumstances that cause kidney stress. The purpose of this study is to determine whether
these medications will help to maintain the function of diseased kidneys during heart
surgery.