An Investigation of the Effects of Opioid Receptor Blockade on Changes in Self-esteem and Social Attention

• Status: Completed
• Trial end date: 2013-03-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to explore the effects of endogenous opioids on self-esteem and attentional bias toward social cues. This is achieved by administering the drug naltrexone, which temporarily decreases endogenous opioid activity.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: McGill University
• Treatments: Naltrexone

Criteria

Inclusion Criteria:

• good physical health,

• normal kidney and liver function results from within previous year

Exclusion Criteria:

• allergy to naltrexone

• kidney or liver injury or disorder

• bipolar, panic, or psychotic disorders

• epilepsy

• smoking more than 15 cigarettes per day

• pregnancy

• substance abuse

• use of opioid analgesics, cocaine, recreational drugs (e.g., marijuana, LSD, ecstasy, etc.), or prescription medication (except oral contraceptives) within the past 10 days

• use of over-the-counter drugs (e.g., analgesics, anti-inflammatories, sleeping aids, etc.) or alcohol within the past 24 hours

• current experience of pain (e.g., headache)

• use of anti-diarrheal medications in the 7 days prior to the study.