An Open-label, Dose-escalation Safety and Tolerability Trial Assessing Anti-KIR (1-7F9) in Subjects With Multiple Myeloma

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Development of new treatments for diseases such as multiple myeloma is a focus for research. The research being conducted is on treatment called Anti-KIR (1-7F9), which activates the body's own cells to kill tumor cells. This is different from many other treatments where chemicals are given to kill tumor cells. The purpose of the study is to determine a safe dose of Anti-KIR (1-7F9) to administer in humans and to gain information about its effectiveness in the treatment of multiple myeloma.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Innate Pharma
• Treatments: Antibodies, Monoclonal

Criteria

Inclusion Criteria:

1. Informed consent obtained before any trial-related activities. (Trial-related activities are any procedure that would not have been performed during normal management of the subject.)

2. Bone marrow plasmacytosis > 10% (as determined by bone marrow aspirate) or plasmacytoma

3. Relapse or progression after at least one prior systemic treatment regimen for Multiple Myeloma (MM) as evidenced by ≥ 25% increase in the M-protein as compared to the best response from the previous treatment regimen.

3a. One prior therapy for multiple myeloma, Measurable disease, as defined by persistent presence of serum and/or urine monoclonal protein or abnormal serum free light chain ratio following the prior treatment.

a. Only for the last seven patients enrolled into the cohort 7 or Maximal Tolerated Dose (MTD).

4. Full recovery from acute toxicities of prior anti-MM therapies. 5. Peripheral blood (Natural Killer) NK cells (Absolute CD16, 56)≥ 0.05 x 109/L (50/mm3) 6. Detectable binding of Anti-KIR (1-7F9) to subject NK cells 7. Age ≥ 18 years 8. Eastern Cooperative Oncology Group (ECOG) performance status of 0,1 or 2 9. Clinical laboratory values at screening:

• serum creatinine < grade 2 toxicity i.e. 1.5x upper limit of institutional normal value

• total bilirubin < 1.5x upper limit of institutional normal value

• Aspartate aminotransferase (AST) < or = 3x upper limit of institutional normal value

• Absolute Neutrophil Count (ANC) >1.2 x109/L

• Platelets >70x109/L

Exclusion Criteria:

1. Known or suspected allergy to trial product or related products

2. Previous participation in this trial (dosed)

3. Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods (appropriate methods include abstinence and the following methods: diaphragm, condom (by the partner), intrauterine device, sponge, spermicide or oral contraceptives)

4. Male subjects who are sexually active and have not been surgically sterilized must be informed that they must either use a condom during intercourse, ensure that their partners practices contraception, or they must refrain from sexual intercourse during the study and until 1 month after completion of the trial.

5. Use of an investigational agent within 30 days of the first dose of study drug (or five half-lives of any antibody).

6. Current treatment with any other anti-MM therapy excluding prophylactic bisphosphonates.

7. Radiotherapy against bone lesions within 4 weeks or visceral lesions within 8 weeks of Screening.

8. Thalidomide or bortezomib treatment within 14 days of Screening.

9. Cytotoxic chemotherapy (excluding thalidomide or bortezomib) or corticosteroid treatment within 28 days of Screening.

10. Subjects with non-secretory multiple myeloma

11. Subjects on dialysis

12. Use of myeloid growth factor within 28 days of screening

13. G-CSF treatment within 28 days of screening

14. Active autoimmune disease

15. Active infectious disease (e.g. HIV, chronic hepatitis, etc.) as judged by the investigator.

16. New York Heart Association (NYHA) class III-IV heart failure

17. Severe neurological / psychiatric disorder as judged by the investigator

18. Clinical evidence of an active second malignancy, with the exception of basal cell carcinoma or in situ carcinoma of cervix.

19. Subjects with a history of allogenic transplantation.

20. Subject who have undergone autologous transplantation within the last 3 months.

21. Mental incapacity or inadequate understanding of English.

22. Any serious medical condition that in the opinion of the investigator, disqualifies the subject for inclusion in the trial.