An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization

• Status: Recruiting
• Trial end date: 2022-03-28
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this Clinical trial is to explore the therapeutic benefits of Ivermectin and Doxycycline in different combinations in high risk patients diagnosed with COVID-19.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Max Health, Subsero Health
• Treatments: Doxycycline; Ivermectin

Criteria

Inclusion Criteria:

• Age greater than or equal to 18

• Willing and able to provide verbal /telephonic/Personal or computer based Informed Consent

• Experiencing symptoms of COVID-19 illness and tested positive for SARS CoV-2 with either PCR, NAAT or antigen testing

• Residents in a Nursing Home or long-term care facility

• Immunocompromised state, including solid organ transplant, HIV infection, other immune deficiency, immunosuppressant medication including systemic corticosteroids

• Chronic lung disease, including Chronic Obstructive Pulmonary Disease (COPD), moderate to severe asthma, cystic fibrosis, pulmonary fibrosis

• Cardiovascular Disease

• Cancer

• Hypertension

• Obesity (body mass index [BMI greater then or equal to 30 kg/m^2]

• Diabetes Mellitus

• Chronic Kidney Disease

• Chronic Liver Disease

• Cerebrovascular Disease

• Neurological Disorders including dementia

• Tobacco use disorders

• Hematologic disorders, including sickle cell disease and thalassemia

We are also interested in including a vital population to protect, considered essential workers who may not fit into the above inclusion criteria:

• Health care professionals and firefighters.

• Government officials or employees.

• Students and teachers.

• Law enforcement agents and personnel.

• Individuals who live with, and cannot isolate, from any of the above groups.

Exclusion Criteria:

• Participants under the age of 18

• Received any COVID vaccine within the last 30 days

• Contraindications to Ivermectin or Doxycycline

• History of Seizure Disorder or Epilepsy

• History of Myocardial Infarction or Heart Attack within the last one month

• Already receiving Ivermectin or Doxycycline for treatment of any other disease or disorder

• Allergies to Ivermectin or Doxycycline including angioedema, severe asthma, exfoliative dermatitis, Steven Jonson syndrome or psoriasis

• History of angioedema, exfoliative dermatitis, Steven Johnson syndrome, psoriasis

• Currently Pregnant or planning to conceive soon

• Breastfeeding

• History of prior Clostridium Difficile infection