An fMRI Study of Opioid-related Changes in Neural Activity

• Status: Completed
• Trial end date: 2018-06-21
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to explore the effect of blocking opioids on affiliation-related neural activity.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tristen Inagaki; University of Pittsburgh
• Treatments: Naltrexone

Criteria

Inclusion Criteria:

• good health

• between the ages of 18 and 35,

• fluent in English

• right-handed (for the fMRI scan)

Exclusion Criteria:

• Self-reported current or past diagnoses of physical or mental illness.

• Score on the Patient Health Questionnaire (depressive symptoms) above a 13

• Positive urine drug test (for Tetrahydrocannabinol (THC), Opiates, Cocaine, Amphetamine (AMP), and Methamphetamine (mAMP))

• Positive urine pregnancy test

• Use of any prescription medication, except for birth control

• Use of any over-the-counter medications on the day of the fMRI session and 24 hours after the fMRI session

• Self-reported problems with liver functioning, including hepatitis or liver failure

• Difficulty swallowing or taking pills

• BMI greater than 35 or weight greater than 400 lbs

• Claustrophobia

• Nonremovable metal in the body