Anaesthesia With Propofol Versus Midazolam : Effect on Oxidative Stress in the Brain of Head Trauma Patients
Status:
Terminated
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
Severe traumatic brain injury is associated with an increased production of free radicals
causing brain damage. First line treatment of these patients aims to maintain cerebral
perfusion and includes deep anaesthesia. Propofol has recently shown anti oxidant properties
that need to be confirmed when used in these patients. The main objective of this study is to
evaluate the effect of propofol compared to midazolam on intra cerebral oxidative stress
following severe traumatic brain injury.