Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients scheduled to have foot and ankle surgery will typically receive a single shot sciatic nerve block to serve as the primary anesthetic and as part of a multi-modal post-operative analgesic plan. The investigators are investigating the use of perineural dexamethasone together with local anesthetics can improve the quality of recovery for patients receiving sciatic nerve blocks for foot and ankle surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• ASA 1-3 patients who are presenting for foot and ankle surgery and are candidates for a single injection sciatic nerve block to provide postoperative analgesia.

• Surgery confined to the foot and ankle.

• Patients aged 18-70 years.

Exclusion Criteria:

• ASA Classification of 4 or higher.

• Pre-existing neuropathy

• Coagulopathy

• Infection at the site

• Diabetes

• Non-English speaking or reading patients

• Systemic use of corticosteroids within 6 months of surgery

• Chronic opioid use

• Pregnancy

• Large (>3cm) skin incision around the medial aspect of the foot

• Any other contra-indication to regional anesthesia