Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA)

• Status: Completed
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. The investigators therefore investigate the effect of Escitalopram as a perioperative analgesic.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Collaborator: Lundbeck Foundation
• Treatments: Analgesics; Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Primary, unilateral total knee arthroplasty (TKA)

• Age > 18 > 81

• Ethnic Danes

• Score > 20 on Pain Catastrophising Scale

Exclusion Criteria:

• Medication that causes risk in combination with SSRI (6 month)

• Treatment for anxiety or depression

• History of depression or mania

• Treatment with systemic glucocorticoids (6 month)

• Treatment with opioids (4 weeks)

• Alcohol or drug abuse

• History of malignancy

• Fertile woman

• History of epilepsia

• Treatment with anticoagulants

• BMI > 40

• Disease affecting central or peripheral nerve function

• Dementia

• History of gastrointestinal bleeding

• History of hepato- or renal insufficiency

• Allergy to Escitalopram