Analgesic Effect of Intraoperative Intravenous S-Ketamine After Total Knee Arthroplasty Surgery

• Status: Recruiting
• Trial end date: 2024-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Severe acute pain after total knee arthroplasty surgery has multiple implications for hospitals and patients, monopolising resources and affecting the quality of life. S-ketamine inhibits N-methyl-d-aspartate (NMDA) receptor activation and attenuates central sensitization associated with hyperalgesia, opioid tolerance.Therefore, the primary aim of this trial was to investigate whether s-ketamine decreases pain and opioid consumption postoperatively in adult individuals undergoing total knee arthroplasty surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Qianfoshan Hospital
• Treatments: Esketamine; Ketamine

Criteria

Inclusion Criteria:

1. Patients understood the study in detail and voluntarily signed the informed consent before the study;

2. Patients to be treated with total knee arthroplasty Surgery under General anesthesia;

3. Elderly patients（≥65y）, regardless of gender; 4.18 kg/m2 ≤BMI≤30 kg/m2;

5.Patients can communicate normally; 6.Patients with ASA grade I-III; 7.Patients who have no contraindications to drugs such as midazolam, fentanyl, s-ketamine.

Exclusion Criteria:

1. Increased intracranial or intraocular pressure;

2. severe hypertension;

3. unwillingness the study;

4. severe psychiatric disease and mental system diseases;

5. severe respiratory diseases;

6. hyperthyroidism;

7. liver and kidney dysfunction;

8. alcohol or drug abuse;

9. allergy to midazolam, fentanyl, s-ketamine.