Analgesic Effect of Oxytocin Receptor Modulation

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

Carbetocin is a synthetic analogue of the hormone Oxytocin and is routinely used in obstetric anesthesiology to control uterine bleeding after cesarean section. As an incidental finding, women who received carbetocin had less pain after cesarean section than women who had received Oxytocin. Carbetocin may therefore have an analgesic effect.

The present study examines this analgesic effect using different sensory tests, e.g. pressure, heat, cold and electrical pain before and after administration of carbetocin in healthy male volunteers. Any changes in these sensory tests might be indicative of an analgesic property of carbetocin.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Analgesics; Carbetocin; Oxytocin

Criteria

Inclusion Criteria:

• male

• pain-free

• written informed consent

Exclusion Criteria

• chronic pain

• acute pain at time of testing

• sign or suspicion of neurological dysfunction at the tested sites

• intake of opioids

• intake of benzodiazepines

• intake of antidepressants

• intake of anticonvulsants

• intake of any analgesic drug 48h prior to test

• known allergy to carbetocin

• allergy to capsaicin

• cardiovascular disease

• asthma bronchiale

• migraine

• epilepsy

• history of liver disease

• history of renal disease