Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic effect.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ullevaal University Hospital
• Collaborator: University of Oslo
• Treatments: Acetaminophen; Analgesics; Codeine; Ibuprofen

Criteria

Inclusion Criteria:

• Patients of ASA class I in need of surgical removal of impacted third molars and with at least moderate postoperative pain as defined by subjective score on a verbal rating scale after surgical removal of third molars.

Exclusion Criteria:

• Females stating not suspected or not verified pregnancy after being questioned by investigator.

• Patients who have used analgesics for 3 days prior to the day of surgery.

• Patients with known active gastrointestinal bleeding or ulcer.

• Patients with any known hypersensitivity to NSAIDs.

• Patients with other drug treatment than contraceptives.

• Patients smoking before taking the test-drug or during the observation period.

• Drug addicts or rehabilitated drug addicts.

• Patients with surgery time exceeding 60 minutes

• Peroperative complications such as profuse bleeding or perforation to the maxillary sinus requiring additional drug treatment during or after the surgical removal of the third molar.

• Postoperative complications such as extended bleeding, nausea and regurgitation during the observation period.