Analgesic Effect of Pregabalin in Patients Undergoing Total Abdominal Hysterectomy

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

Pregabalin will decrease the total amount of opioid required in patients undergoing total abdominal hysterectomy. In addition, pregabalin will decrease the incidence of opioid-related side effects in patients undergoing total abdominal hysterectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Treatments: Analgesics; Pregabalin

Criteria

Inclusion Criteria:

• ASA Physical Status 1-2

• Age 18-64

• BMI 18-35

• Scheduled for elective total abdominal hysterectomy (with or without bilateral salpingo-oophorectomy)

• Gender: Female

• Consent: Obtained

Exclusion Criteria:

• Patient refusal

• Allergy to study medication(s)

• Preoperative use of gabapentinoids

• Preoperative use of anticonvulsants

• Daily use of analgesics

• Hepatic disease

• Renal insufficiency (Cr >2.0)

• Alcohol or drug abuse

• Pregnancy

• Language: Non-English speaking

• Patient expected to remain intubated after procedure

Dropout:

• Patient request

• Surgeon request

• Allergic reaction to pregabalin

• Surgical procedure significantly altered from scheduled procedure