Analgesic Efficacy of Dexamethasone in Different Routes of Administration in Transverse Abdominis Plane Block
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Transverse abdominis plane (TAP) block is a regional anaesthesia technique that provides
analgesia to the parietal peritoneum as well as skin and muscles of the anterior abdominal
wall. In the past, a number of adjuvants have been added to the local anaesthetics in
peripheral and neuraxial blocks resulting in an effective and long lasting analgesia.In
recent times, dexamethasone has been increasingly used as an adjuvant to local anaesthetics
in peripheral nerve blocks. Dexamethasone has a long and efficient glucocorticoid structure
and also has anti-inflammatory property. It also blocks the C- fibers of pain pathway. When
added to local anaesthetics as an adjuvant in peripheral nerve blocks, it has shown to
prolong the analgesia time. A number of previous studies have also shown an opioid sparing
effect of steroids, when used intravenously perioperatively. Though previous studies have
shown that addition of dexamethasone to local anaesthetics in transverse abdominis plane
block prolongs the duration of block, however it is not known whether this effect of
dexamethasone is due to its peripheral action or because of its systemic absorption. Thus, in
this study planned to compare the effectiveness of dexamethasone on quality and duration of
analgesia when used as an adjuvant with local anaesthetics in transverse abdominis plane
block versus when given systemically by intravenous route along with transverse abdominis
plane block using local anaesthetics only, in patients undergoing gynaecological laparoscopic
procedures under general anaesthesia.
Phase:
N/A
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research