Analgesic Efficacy of Two Concentrations of Bupivacaine in Women in Labor
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
Abstract.
Epidural analgesia is the most safe and effective for the treatment of pain of childbirth
method. Epidural Bupivacaine provided excellent analgesia for labor and remains the most
widely used local anesthetic in obstetric anesthesia.
Objective: To evaluate the analgesic efficacy of two concentrations of bupivacaine in women
in labor.
Methods: 114 patients were included in labor with term pregnancy. Were grouped randomly into
two groups: patients who received bupivacaine 0.125 % (Group A) and 0.25% bupivacaine (group
B). Patients in group A received 10 ml of 0.125% bupivacaine bolus. The patients in group B
received 10 ml. Bupivacaine 0.25% bolus. Pain intensity according to VAS, blood pressure,
heart rate, respiratory rate, degree of motor block was assessed using the Bromage scale at
different periods of time.
Results: Demographic characteristics and parity were compared, no statistically significant
differences. By comparing the values of the VAS measure 0, 15, 30, 60 and 90 minutes into
statistically significant differences in favor of the group with 0.25% Bupivacaine with
decreased pain perception after 30 minutes, p-value found 0.02. No differences in arterial
pressure, heart rate and respiratory rate were found between the two groups.
Conclusion: The concentration of 0.25% Bupivacaine has greater analgesic efficacy compared
with 0.125% bupivacaine.