Analgesic and Subjective Effects of Terpenes

• Status: Not yet recruiting
• Trial end date: 2025-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, Los Angeles
• Collaborator: National Center for Complementary and Integrative Health (NCCIH)
• Treatments: Caryophyllene

Criteria

Inclusion Criteria:

• Male or non-pregnant female aged 21-55 years

• Report non-medical use of cannabis 2-6 days per week

• Not currently seeking treatment for cannabis use

• Urine test positive for recent cannabis use

• Have a Body Mass Index from 18.5 - 34kg/m2.

• Able to perform all study procedures

• Must be using a contraceptive method (hormonal or barrier methods)

Exclusion Criteria:

• Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or mild CUD

• Report using other illicit drugs in the prior 4 weeks

• If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process revealed any significant illness (e.g., hypertension)

• Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes

• Current pain

• History of respiratory illness or current respiratory illness

• History of seizure disorder or current seizure disorder

• Insensitivity to the cold water stimulus of the Cold Pressor Test