Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl

• Status: Completed
• Trial end date: 2020-11-18
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to test how fentanyl, an analgesic currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Collaborator: United States Department of Defense
• Treatments: Analgesics; Fentanyl

Criteria

Inclusion Criteria:

• Healthy

• Non-obese (body mass index less than 30 kg/m2)

• Body mass greater than or equal to 65 kg

Exclusion Criteria:

• Subjects who have cardiac, respiratory, neurological and/or metabolic illnesses

• Any known history of renal or hepatic insufficiency/disease

• Pregnancy or breast feeding

• Current smokers, as well as individuals who regularly smoked within the past 3 years

• Positive urine drug screen

• Currently taking pain modifying medication(s)