Analgosedation for Elective Colonoscopy

• Status: Completed
• Trial end date: 2021-12-15
• Target enrollment: 0
• Participant gender: All

Summary

Aim: The aim of the study was to to compare the analgesic effects of ketamine over fentanyl combined with propofol in analgesia-based elective colonoscopy with purpose of patient safety and satisfaction.

Methods: This is a double-blinded prospective randomized controlled trial. Ninety patients were included and randomized to either fentanyl-propofol (Group FP, n: 30), ketamine-propofol (Group KP, n: 30) or propofol-control group (Group C, n: 30). Group FP patients received fentanyl and propofol, Group KP received ketamine and propofol and Group C, propofol. In all groups, incremental doses of propofol were used to maintain a Ramsay sedation score (RSS) of

5. Respiratory depression, hemodynamic parameters were monitored for the first minute and every 5 minutes during endoscopy. Fifteen minutes after the procedure, the degree of pain was assessed using a visual analog scale (VAS), the quality of recovery according to the Aldrete score (ARS), complications during and after the procedure and additional doses of propofol were recorded.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cantonal Hospital Zenica
• Treatments: Fentanyl; Ketamine

Criteria

Inclusion Criteria:

• ASA physical statuses I and II,

• patients who were older than 18 years

Exclusion Criteria:

• colonoscopies lasting longer than 30 minutes,

• patients with previous abdominal surgery,

• patients treated for neuropathic pain, malignant and respiratory diseases,

• pregnant women, gastrointestinal obstruction,

• patients using antihypertensive and antiarrhythmic drugs,

• psychiatric patients,

• patients with ASA physical status III and higher,

• patients who refused to participate in the study