Overview

Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients

Status:
Completed
Trial end date:
2021-05-06
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to investigate the efficacy and safety of a low dose ketamine infusion used in combination of standard of care in critically ill patients to test whether ketamine can help to shorten the time of being in breathing tube and ventilator compared to the standard of care alone.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
King Faisal Specialist Hospital & Research Center
Treatments:
Ketamine
Criteria
Inclusion Criteria:

1. Adult ICU (Medical or surgical) patients (> 14 years old)

2. Mechanically ventilated within the previous 24 hours and expected to remain intubated
for more than 24 hours.

3. The patient requires ongoing sedative medication

4. No objection from the ICU attending MD for enrollment

Exclusion Criteria:

1. Patients with a history of dementia or psychiatric disorders or on any anti-psychotics
or anti-depressants medications at home

2. Pregnancy

3. Age < 14 years old

4. Expected to need mechanical ventilation less than 24 hours

5. Known hypersensitivity to ketamine

6. Patient on dexmedetomidine as primary sedative agent prior to randomization

7. Patients with cardiogenic shock, heart failure, myocardial infarction

8. History of end-stage liver disease.

9. Proven or suspected primary neurological injury (traumatic brain injury, ischemic
stroke, intracranial hemorrhage, spinal cord injury, anoxic brain injury)

10. Patients with persistent heart rate (HR) > 150 bpm or systolic blood pressure (SBP)
>180 mmHg

11. Patients who assigned as do-not-resuscitate order (DNR) or expected to die within 24
hours

12. Patients on ECMO

13. Patients with status epilepticus patients who are receiving the ketamine infusion for
refractory status epilepticus

14. Proven or suspected status asthmaticus

15. Patients with expected targeted RASS of -5 such as patients on continuous infusion
neuromuscular blockade