Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia

• Status: Recruiting
• Trial end date: 2023-10-23
• Target enrollment: 0
• Participant gender: All

Summary

Efficient gait requires effective postural control, both static and dynamic. Hence, postural disorders may affect gait. Yet, very little is known about the specific effects of focal postural disorders such as cervical dystonia (CD) and blepharospasm (BS) on patients' mobility.

The present research therefore aims at analyzing gait characteristics in patients presenting with these conditions in order to document possible gait alterations.

In addition, the investigators will explore the effect of botulinum toxin treatment, which the most frequently used therapeutic option, on the patients' gait characteristics. Indeed, while the treatment improves both dystonia and pain, and therefore quality of life, its influence on gait is presently unknown. the investigators aim at filling this knowledge gap

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Grenoble
• Treatments: Botulinum Toxins

Criteria

Inclusion Criteria:

• speaking French, in the ability to understand clinical tests and explorations,

• in ability to move to the CHU Grenoble Alpes

• Diagnosis of cervical dystonia or isolated Blepharospasm,

• Absence of neurological or psychiatric disorders,

• Affiliation to a health insurance,

• Signed consent fo the subject.

Exclusion Criteria:

• Pregnant women (positive pregnancy test), parturient or breastfeeding

• Cervical dystonia or Blepharospasm of secondary origin

• subjects having benefited from deep brain stimulation,

• History of other pathologies that may lead to walking disorders, inability to walk without technical assistance, inability to walk for more than 10 minutes,

• Subjects receiving botulinum toxin treatment for another cause.

Prohibited treatments and procedures:

• Antecedent of pathologies that may cause walking disorders

• Simultaneous participation in another Interventional study

• Subject in time of exclusion from another study

• Subject under guardianship or having curators (major protected)

• Subject under administrative or judicial supervision

• Subject not able to be contacted in case of emergency