Analysis of Postoperative Ocular Surface Changes and Intervention Effect After PPV in MGD Dry Eye Patients

• Status: Completed
• Trial end date: 2022-07-02
• Target enrollment: 0
• Participant gender: All

Summary

AIM: To observe ocular surface changes after phacovitrectomy in patients with mild to moderate meibomian gland dysfunction (MGD)-type dry eye and track clinical treatment response using a Keratograph 5M and a LipiView interferometer.

METHODS: Forty cases were randomized into control group A and treatment group B; the latter received meibomian gland treatment 3 days before phacovitrectomy and sodium hyaluronate before and after surgery. The average non-invasive tear film break-up time (NITBUTav), first non-invasive tear film break-up time (NITBUTf), non-invasive measured tear meniscus height (NTMH), meibomian gland loss (MGL), lipid layer thickness (LLT) and partial blink rate (PBR) were measured preoperatively and 1 week, 1 month and 3 months postoperatively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tianjin Medical University Eye Hospital
• Treatments: Lubricant Eye Drops

Criteria

Inclusion Criteria:

• Clinical diagnosis of dry eye

• Clinical diagnosis for MGD

Exclusion Criteria:

• eye trauma or eye surgery within the prior 6 months

• use of drugs that affect tear secretion and the stability of the tear film (including anti-glaucoma drugs, cortisol drugs, etc.) within the prior 6 months

• other diseases that affect the function of the eye surface, such as meibomian gland cysts, blepharitis, eyelid valgus, incomplete closure, chronic tear cystitis, corneal disease, glaucoma, or optic neuropathy

• intraoperative suture fixation or closure of a corneal, conjunctival, or scleral incision

• long-term postoperative intraocular hypertension that could not be controlled easily with oral drugs and required puncture and drainage through the anterior chamber

• postoperative corneal epithelial defects lasting more than 1 week or necessitating the use of contact lenses for treatment

• the need for a second operation during the study follow-up eye trauma or eye surgery within the prior 6 months

• use of drugs that affect tear secretion and the stability of the tear film (including anti-glaucoma drugs, cortisol drugs, etc.) within the prior 6 months

• other diseases that affect the function of the eye surface, such as meibomian gland cysts, blepharitis, eyelid valgus, incomplete closure, chronic tear cystitis, corneal disease, glaucoma, or optic neuropathy

• intraoperative suture fixation or closure of a corneal, conjunctival, or scleral incision

• long-term postoperative intraocular hypertension that could not be controlled easily with oral drugs and required puncture and drainage through the anterior chamber

• postoperative corneal epithelial defects lasting more than 1 week or necessitating the use of contact lenses for treatment

• the need for a second operation during the study follow-up