Overview

Analysis of a Beneficial Effect of Prolonges Topical Steroid Treatment After Low-risk Penetrating Keratoplasty

Status:
Completed

Trial end date:
2007-03-01

Target enrollment:
0

Participant gender:
All

Summary

PURPOSE: To assess the impact of duration of topical steroid treatment on the incidence of endothelial graft rejection following normal-risk penetrating keratoplasty (PK). DESIGN: Prospective, institutional, longitudinal, randomized interventional trial including 406 eyes (age: 52 >= 19 years; follow-up: 42 >= 18months). METHODS: Postoperative treatment started with prednisolone acetate 1% eye drops five times daily and was tapered over the first 6 months. Patients were then randomised into either short-term (stop topical steroid treatment) or long-term treatment (continue steroids once daily until 12 months).

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

University of Erlangen-Nürnberg Medical School

Criteria

Inclusion Criteria:

- Low risk keratoplasty

Exclusion Criteria:

- High risk keratoplasty