Analysis of a Beneficial Effect of Prolonges Topical Steroid Treatment After Low-risk Penetrating Keratoplasty
Status:
Completed
Trial end date:
2007-03-01
Target enrollment:
Participant gender:
Summary
PURPOSE: To assess the impact of duration of topical steroid treatment on the incidence of
endothelial graft rejection following normal-risk penetrating keratoplasty (PK). DESIGN:
Prospective, institutional, longitudinal, randomized interventional trial including 406 eyes
(age: 52 >= 19 years; follow-up: 42 >= 18months). METHODS: Postoperative treatment started
with prednisolone acetate 1% eye drops five times daily and was tapered over the first 6
months. Patients were then randomised into either short-term (stop topical steroid treatment)
or long-term treatment (continue steroids once daily until 12 months).