Androgen Effect on Klinefelter Syndrome Motor Outcome

• Status: Completed
• Trial end date: 2017-11-30
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to evaluate the effects of low-dose androgen on the motor and cognitive development of boys with Klinefelter syndrome.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thomas Jefferson University
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Androgens; Ascorbic Acid; Estrogens, Conjugated (USP); Methyltestosterone; Oxandrolone

Criteria

Inclusion Criteria:

• Karyotype diagnosis of Klinefelter syndrome

• Chronological age of 4-12 years

• No treatment with androgen in the past year

Exclusion Criteria:

• Major liver, kidney or other systemic disease

• Variant karyotypes including 47,XYY males

• Evidence of spontaneous onset of puberty, defined as testicular size > 4ml