Anesthesia Depth's Influence on Postoperative Delirium

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators,according to the eligibility criteria,plane to choose 80 elderly anticipates who will undergo selective hip replacement surgery.This participants will be randomly divided into 2 groups:light anesthesia depth group(L Group) and deep anesthesia depth group (D Group).Before anesthesia induction,each participant will be given lumbar plexus and sciatic nerve block in order to control pain of interoperative and postoperative.During operation period,the L Group will be kept in light anesthesia depth(BIS:50-60),while the D group will be kept in deep anesthesia depth(BIS:35-45)--The BIS values in the range of 30-60 have been recommended in general anesthesia.After operation,a PCIA(patient controlled intravenous analgesia) analgesia pump will be given to each participant to control postoperative pain. The investigator will evaluate the mental state of participant with MMSE(mini-mental state examination) before surgery and review each participant with a CAM-CR for 3 days after surgery to assess the situation of postoperation delirium.intraoperative awareness,postoperative pain will also be investigated in postoperative days 1, 2, 3.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xiangya Hospital of Central South University
• Treatments: Anesthetics; Propofol; Remifentanil; Ropivacaine; Sufentanil

Criteria

Inclusion Criteria:

1. participant who is selected to undergo hip replacement surgery.

2. participant who is older than 60 years old.

3. participant whose ASA（The American Society of Anesthesiologists） is II-III.

4. participant whose BMI is 18-25.

5. participant who is able to understand and complete The Confusion Assessment Method(CAM-CR).

6. participant who is able to finish Visual Analogue Scale(VAS).

7. participant who is conscious and willing to take part in this research.

8. participant and his/her relatives are willing to take part in this research.

Exclusion Criteria:

1. participant who has serious liver or kidney disease.

2. participant who suffer from mental or neurologic disease,such as Alzheimer disease.

3. participant who has undergone cardiovascular surgery or neurosurgery.

4. participant who has have sedation or antidepression medicine for a long time.

5. participant who has something wrong with his/her vision or hearing.

6. participant who has blood coagulation dysfunction.

7. participant who is an illiteracy.