Anesthesia and Postoperative Outcome in Colorectal Cancer Patients

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Study aims to compare the influence of TIVA and sevoflurane anesthesia with or without lidocaine on postoperative short and long term outcome in patients with colorectal cancer undergoing surgery.

As short term endpoints postoperative pain and opioid consumption, resumption of bowel function, PONV, LOS will be registered.

Long term outcome parameters include: the incidence of chronic pain, 1 and 5 years cancer recurrences incidence and mortality.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
• Collaborator: Prof. Dr. I. Chiricuta Institute of Oncology
• Treatments: Anesthetics; Fentanyl; Lidocaine; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Elective surgery

Exclusion Criteria:

• • persistent chronic pain

• chronic medication that may interfere with pain: antiepileptics, NSAID, corticoids

• Contraindications for any of the study medications

• Significant psychiatric disorders (Axa I) (major depression, bipolar disorders, schizophrenia, etc.)

• Significant hepatic (ALAT and/or ASAT > 2 normal values) or renal (plasma creatinine > 2 mg/dl) disorders

• Convulsive disorders requiring medication during the last 2 years

• Planned regional analgesia/anesthesia (spinal or epidural)

• Corticoid dependent asthma

• Autoimmune disorders

• Anti-arrhythmic medication (verapamil, propafenone, amiodarone) that may interfere with lidocaine's anti-arrhythmic effects

• Refusal for study participation