Anesthesia in Patients With Mitochondrial Disease

• Status: Recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This pilot study is a prospective, randomized clinical trial to evaluate the effect of anesthesia in the mitochondrial dysfunction patient.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Treatments: Anesthetics; Dexmedetomidine; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Subjects must fulfill the following inclusion criteria:

• Subject is informed and given ample opportunity to consider his/her participation and has given his/her written consent.

• Subject is willing and able to comply with all study requirements.

• Subject is between 0 - 17 years of age.

• Subject has been diagnosed with mitochondrial dysfunction based on modified Walker criteria.

• Subject is scheduled to have a non-emergent diagnostic or therapeutic procedure for routine medical care requiring general anesthesia estimated to last at least one hour.

• Subject is classified ASA I - IV

Exclusion Criteria:

Subjects are not permitted to enroll in the study if any of the following criteria are met:

• Subject is older than 17 years

• Subject is pregnant

• Subject is a nursing female and

• Subject has participated in the same study within 48 hours

• Subject is allergic or has had any adverse effect to any of the study agents in the past

• Anesthesia time is less than one hour

• Subject is classified ASA V