Anesthetic Depth Effects Upon Immune Competent Cells

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients. ASA 1-3 subjects undergoing extended shoulder surgery under continuous regional anesthesia randomly were assigned to a deep or a shallow anesthesia level (BIS <35 or >55) for more than an hour. Immune response is measured by lymphocyte proliferation as well as neutrophil and monocyte phagocytosis activity.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitätsmedizin Mannheim
• Collaborator: Heidelberg University
• Treatments: Anesthetics; Fentanyl; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• enrolment for longer shoulder surgery

• consent for the standard anesthesia form in combination with the interscalene plexus block

• ASA Status 1-3

Exclusion Criteria:

• sedative premedication

• severe immune deficiency (diabetes, steroid or antihistamine medication, cancer, chemotherapy,

• status post transplantation, drug and alcohol abuse),

• recent surgery (1 month) or blood transfusion