Anesthetics to Prevent Lung Injury in Cardiac Surgery

• Status: Completed
• Trial end date: 2021-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate whether the use of inhaled anesthetics, compared to intravenous anesthetics, can affect the amount of lung inflammation and postoperative respiratory complications seen after cardiac surgery.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beth Israel Deaconess Medical Center
• Treatments: Anesthetics; Anesthetics, Intravenous; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Adult patients (age 18+)

• Undergoing cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

• Emergency surgery

• History of severe COPD, emphysema, or ILD

• Recent (<2wk) or current use of systemic glucocorticoids

• Prior history of pneumothorax

• Allergy/contraindication to intravenous anesthetics

• Personal or family history of malignant hyperthermia or high risk for malignant hyperthermia