Aging is an independent risk factor for developing hypertension and cardiovascular disease;
however, the mechanisms underlying age-related cardiovascular disease remain poorly
understood. One hallmark of aging is an increase in sympathetic nervous system activity,
which can decrease the number and/or sensitivity of β2 adrenergic receptors to reduce
dilation of blood vessels and increase blood pressure. Identifying new targets to restore
vascular β2 adrenergic receptor signaling may help reduce cardiovascular risk in aging. This
study will test the hypothesis that angiotensin-(1-7), a protective hormone of the
renin-angiotensin system, can reduce cardiovascular sympathetic outflow and blood pressure
and improve endothelial function in older healthy humans.