Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Status:
Recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular
disease later in life, even if they are otherwise healthy. The reason why this occurs is
unclear but may be related to blood vessel damage and increased inflammation that occurs
during the preeclamptic pregnancy and persists postpartum. The purpose of this investigation
is to 1) determine the mechanisms contributing to this lasting blood vessel damage and
chronic inflammation, and to 2) identify factors (both physiological and pharmacological)
that mitigate these negative effects in order to inform better clinical management of
cardiovascular disease risk in women who have had preeclampsia.
Phase:
Early Phase 1
Details
Lead Sponsor:
Penn State University University of Iowa
Collaborator:
Penn State University
Treatments:
Angiotensin II Angiotensinogen Giapreza Salicylsalicylic acid Sodium Salicylate