Angiotensin Receptors and Age Related Mitochondrial Decline in HIV Patients

• Status: Terminated
• Trial end date: 2016-08-04
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to evaluate specific factors in mitochondria that may precipitate premature aging and physical weakness in HIV patients. Angiotensin receptors 1 and 2 (AT1R and AT2R) are found in virtually every cell type. This study will evaluate how the relationships among these receptors in immune and skeletal muscle cells change with HIV, and how these changes might trigger mitochondrial dysfunction, declines in muscle strength, and cellular decline in people living with HIV.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Collaborator: Johns Hopkins University
• Treatments: Valsartan

Criteria

Inclusion Criteria:

• able to provide informed consent

• able to attend an extended (~4 hour) Clinical Research Visit

• documented HIV seropositivity

• on a stable anti-retroviral therapy (ART) regimen for at least 12 months

• HIV plasma viral load < 50 copies/ml for at least 6 months

• Systolic blood pressure >110

Exclusion Criteria:

• creatinine > 1.5 ULN (or creatinine clearance < 60 ml/min)

• anti-hypertensive therapy with ACE-I or AT1R-blockers

• inability to perform functional measures (e.g. non-ambulatory without assistance, requires a prosthesis)

• recent (within 30 days) acute illness requiring medical therapy or hospitalization

• immunosuppressive agents (e.g. > 20 mg/d x 2 or more weeks of prednisone or equivalent, chemotherapy) in the last 6 months

• cancer requiring treatment w/in 3 yrs (except for non-melanoma skin cancer)

• blood thinning medications such as Coumadin or Plavix or a bleeding disorder such as hemophilia that could cause complications during muscle biopsies

• pregnancy (will provide urine test for females of child bearing potential)

• regular use of non-steroidal anti-inflammatory drugs or other immune modulating agents.