Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer
Status:
Recruiting
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
PARP inhibitors have changed the treatment paradigm of ovarian cancer. Most patients using
PARP(poly-ADP ribose polymerase) inhibitors will suffer different grades of adverse
events(AEs), followed by dose reduction. It has not been reported whether the dose-reduced
olaparib as maintenance treatment have an impact on efficacy. Both PAOLA-1 and AVANOVA 2
studies showed that combined PARP inhibitors and antiangiogenic drugs have synergistic
anti-tumor effect. Anlotinib is a novel multi-target tyrosine kinase inhibitor that can
inhibit VEGFR(vascular endothelial growth factor receptor), FGFR(fibroblast growth factor
receptor), PDGFR(platelet-derived growth factor receptor) α/β, c-Kit, and Ret. And anlotinib
has been approved as orphan drug designations for treatment of ovarian cancer by FDA in 2015.
Previous studies showed that anlotinib had manageable toxicity and promising antitumor
effect. Our study is expected to investigate the efficacy and safety of anlotinib combined
with dose-reduced olaparib as maintenance treatment in platinum-sensitive recurrent ovarian
cancer patients.