Antagonist/Letrozole in Poor Responders

• Status: Completed
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Failure to respond to controlled ovarian hyperstimulation (COH) is still a major concern in assisted reproduction and there is no consensus on the ovarian stimulation choice regime for poor responders.

Aim: To evaluate and compare the efficacy of a microdose GnRH agonist flare (MF) and a GnRH antagonist/letrozole (A/L) protocols in poor responders undergoing in vitro fertilization (IVF).

Methods: One hundred eighty poor responder patients will be randomized to an ovarian stimulation protocol with either a MF or a letrozole and high dose FSH/hMG and flexible GnRH antagonist protocol.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yazd Research & Clinical Center for Infertility
• Treatments: Buserelin; Contraceptive Agents; Contraceptives, Oral; Deslorelin; Ganirelix; Letrozole; Triptorelin Pamoate

Criteria

Inclusion Criteria:

• at least one previous failed IVF cycle in which three or fewer follicles with a mean diameter of 16 mm were achieved, and/or

• serum E2 level measured on the day of hCG administration was ≤500 pg/ml

Exclusion Criteria:

• day 3 serum FSH level ≥12 mIU/mL

• there is no age limit