Antenatal Azithromycin to Prevent Preterm Birth in Pregnant Women With Vaginal Cerclage

• Status: Completed
• Trial end date: 2020-04-15
• Target enrollment: 0
• Participant gender: Female

Summary

In women with indicated vaginal cerclage, this study aims to assess the efficacy of antenatal prophylactic Azithromycin in preventing preterm labor.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams Maternity Hospital
• Treatments: Azithromycin

Criteria

Inclusion Criteria:

1. Gestational age (14-34 weeks).

2. Pregnant women who underwent vaginal cerclage (either history- based or ultrasound based vaginal cerclage)

History based cerclage:

• History of one or more second-trimester pregnancy losses related to painless cervical dilatation and in absence of labor or abruptio placentae; OR

• Prior cerclage due to painless cervical dilation in the second trimester

Ultrasound based cerclage:

Current singleton pregnancy, prior spontaneous preterm birth at less than 34 weeks of gestation, and short cervical length (less than 25 mm) before 24 weeks of gestation

Exclusion Criteria:

1. Multiple pregnancy.

2. Current or past history of medical diseases (Diabetes Milletus, Hypertension, Systemic Lupus Erythematosus, Cardiac diseases, etc ).

3. Adverse perinatal outcome due to abdominal trauma.

4. Structural fetal anomalies detected during anomaly scan.

5. Allergy to Azithromycin