Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa
Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
HIV infected people often must take anti-HIV drugs for long periods, leading to long-term
drug exposure and toxicity. Interruptions in anti-HIV therapy, also known as structured
treatment interruptions (STIs), may have few negative health effects and may be helpful to
the overall long-term health of HIV-infected people. The purpose of this study is to
determine if sequential short-term STIs of antiretroviral therapy (ART) in HIV infected
individuals in a resource-constrained environment can retain the immune reconstitution
benefits of continuous treatment while potentially lessening rates of toxicity associated
with continuous therapy strategies and at the same time, lessen costs associated with ART.