Overview

Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human

Status:
Unknown status
Trial end date:
2010-11-01
Target enrollment:
0
Participant gender:
All
Summary
Hypothesis: Rho, one of the small GTPase proteins, and its downstream target molecule, Rho-kinase (ROCK), play important roles in mediating various cellular functions, including contractility, actin cytoskeleton organization, cell adhesion and motility, proliferation, cytokinesis and gene expressions, all of which are involved in the pathogenesis of cardiomyocyte contractility and other vascular disease. The investigators thus hypothesize that ROCK pathway plays an important role in the function and severity of heart failure (HF) and can be one of the possible pathway that currently applied cardiovascular medicine affecting their prognosis among HF treatment. Previous study has shown that in patients with HF, intra-arterial infusion of fasudil causes preferential increase in forearm blood flow as compared with control subjects, suggesting an involvement of Rho/Rho-kinase pathway in the increased peripheral vascular HF failure remain to be examined. Besides, whether the rho kinase activity was enhanced or their response to current medication in HF patients remained unsolved. Aim: ROCK activity and left ventricular function between HF or non-HF population survey and their response to ACEi Tx.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Cheng-Kung University Hospital
Treatments:
Antihypertensive Agents
Enalapril
Enalaprilat
Criteria
Inclusion Criteria:

- those subjects aged from 16 to 80 years

- diagnosed as systolic hypertension

Exclusion Criteria:

- renal insufficiency (serum creatinine ≥ 2.5 mg/dl)

- hyperkalemia (serum potassium ≥ 5mmol/L)

- with systemic inflammatory disease, including history of autoimmune disease,
malignance; bilateral renal artery stenosis

- prior intolerance of an angiotensin receptor blockade (ARB) or ACE

- ACEi or ARB use within recent 1 month

- record of symptomatic hypotension