Anti Inflammatory and Analgesic Effect of Ginger Powder in Dental Pain Model
Status:
Unknown status
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Ginger contains constituents with pharmacological properties similar to the novel class of
dual-acting NSAIDs. Compounds in this class inhibit arachidonic acid metabolism via the
cyclooxygenase (COX) and lipooxygenase (LOX) pathways. These compounds have notably fewer
side effects than conventional NSAIDs and now are being investigated as a novel class of
anti-inflammatory compounds. Although ginger has potentially strong anti-inflammatory
components, its efficacy on acute inflammation was not assessed before. The common
postoperative sequelae of surgical removal of impacted teeth are pain, trismus and swelling,
related to local inflammatory reaction, with cyclooxygenase and prostaglandins playing a
crucial role. NSAIDs (e.g. Ibuprofen) are effective in the management of postoperative dental
pain, likely through blockage of prostaglandin synthesis and are commonly used. The efficacy
of Ibuprofen in the treatment of postoperative dental pain has been evaluated in several
clinical trials. However, NSAIDs are contraindicated in patients with gastrointestinal
ulcers, bleeding disorders, and renal dysfunctions. Therefore, there is a need for an
effective, oral analgesic with a more favorable safety profile. The primary aim of this study
was to investigate the ability of Ginger powder (Zintoma, Goldaru) to reduce postoperative
swelling, pain and trismus in an acute pain model.