Anti Inflammatory and Analgesic Effect of Ginger Powder in Dental Pain Model

• Status: Unknown status
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Ginger contains constituents with pharmacological properties similar to the novel class of dual-acting NSAIDs. Compounds in this class inhibit arachidonic acid metabolism via the cyclooxygenase (COX) and lipooxygenase (LOX) pathways. These compounds have notably fewer side effects than conventional NSAIDs and now are being investigated as a novel class of anti-inflammatory compounds. Although ginger has potentially strong anti-inflammatory components, its efficacy on acute inflammation was not assessed before. The common postoperative sequelae of surgical removal of impacted teeth are pain, trismus and swelling, related to local inflammatory reaction, with cyclooxygenase and prostaglandins playing a crucial role. NSAIDs (e.g. Ibuprofen) are effective in the management of postoperative dental pain, likely through blockage of prostaglandin synthesis and are commonly used. The efficacy of Ibuprofen in the treatment of postoperative dental pain has been evaluated in several clinical trials. However, NSAIDs are contraindicated in patients with gastrointestinal ulcers, bleeding disorders, and renal dysfunctions. Therefore, there is a need for an effective, oral analgesic with a more favorable safety profile. The primary aim of this study was to investigate the ability of Ginger powder (Zintoma, Goldaru) to reduce postoperative swelling, pain and trismus in an acute pain model.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Qazvin University Of Medical Sciences
• Treatments: Analgesics; Anti-Inflammatory Agents; Ibuprofen

Criteria

Inclusion Criteria:

• Have at least one mesio-angular impacted mandibular third molar(5-7 difficulty degree)

• adults without any kind of systemic disease

• adults with at least Diploma educational degree

Exclusion Criteria:

• history of cold,fever,infection or any other inflammatory conditions during one month before surgery

• known allergy to NSAIDs ,ginger or acetaminophen

• any kind of hematopoietic or bleeding disorders

• pregnancy or lactating

• history of peptic ulceration

• history of corticosteroid use

• duration of surgery more than 30 minutes

• any infection, fever or any kind of disease cause on days 1,2 and 3 after surgery

• failure to attend for follow up

• using any kind of medication other than given drugs until day 5 post operatively

• being on anticoagulants except for mini-aspirin (72-325 mg/day)

• mentally incapable of understanding or complying with the study protocol or for failing to sign the informed consent